團隊簡介

科學研究

成果榮譽

服務(wù)行業(yè)

國際交流

團隊風采

01

目 錄 CONTENTS

03

11

20

22

23

1

團隊簡介

???二??????????????????七???????喕サ

?.35喖?介??????二????????????喙????????

??????????????俁?????????????????俁

????喕??喖?????????????七????俁?喕??喖?

????/?????俁?喕?????↖?喖?????????????ま

???????????二?????????????喙????

????二??????????

???ω?К?喙????????????????????????

??????????ρま?喙??湊Ψ??????????????

ま?????????喙??????????喙????????喙

??????喙??4$*?????ー?

2

團隊簡介

團隊主任

??喙??喙????

????介?喙?π??????

?七?????????Ь???

??????
?喙??????喙倍?????喙

?????喙??????喙???????喙???

?喙??????
?喙?????
??

團隊成員

3

研究領(lǐng)域

科學研究

一、奶牛健康養(yǎng)殖與牛奶品質(zhì)形成機理

（1）瘤胃尿素分解菌群結(jié)構(gòu)解析與脲酶功能調(diào)控

?????????????Ⅳ??喙??喙????????????

??????????倍??Ⅳ?????????日?????????

????????????????????喙????????????

???????????喕+JO
FU
BM

'SPOU
.JDSPCJPM

喨4BNTPO
FU
BM

'SPOU

.JDSPCJPM

喖喨???　???????????VSF$???喙?????

??????????????? ;IBOH
FU
BM

*OU
+
#JPM
.BDSPNPM



喨ゐ

????????喙??λ???≥/?????????????

?????????????????

4

科學研究

（2）營養(yǎng)素調(diào)控乳腺細胞合成乳蛋白的信號通路機制

??????Ψ????????喙Δ?????????Ψ?????

?????????℉喙??N503$?????????????????

??喕;IBOH
FU
BM

+
%BJSZ
4DJ

喖??λ??N503$???????喙

??Ψ?????????喙??4&4/????N503$
?????喙??

??\"\"?????????????喕-VP
FU
BM

4DJ
3FQ

喖?(/(?

??3BHVMBUPS???????????N503$??喙??????????

???4&4/?????)/)????????????喙??????

N503$
?????-
VP
FU
BM

+
\"HSJD
'PPE
$IFN



?

SENE2抑制mTOR在溶酶體的定位

5

（1）霉菌毒素聯(lián)合毒性及機制研究

??亣且???????????喙????????σ?????

?喙?嘆????.喕\"'.喖??????\"喕05\"喖???????

?????\"'.?05\"???嘔??????????????喙\"'.

?05\"???#\"-#D?嘔????????????????????喙

????????????x喙\"'.?05\"????????????

????????????N3/\"
?????NJ3/\"?MOD3/\"????

???喙??1?8/5?/'°#????喕(BP
FU
BM

4DJ
5PUBM
&OWJSPOU

喨:BOH
FU
BM

&DPUPY
&OWJSPO
4BGF

喖?

科學研究

二、奶產(chǎn)品質(zhì)量安全風險評估與營養(yǎng)功能評價

AFM1和OTA誘導免疫抑制的機制圖

6

科學研究

（2）乳鐵蛋白生物活性功能及評價

Ψ?????????????喙Ψ????????????????

???∝▁?????????5-3????喙????????????

喕:BOH
FU
BM

+
%BJSZ
4DJ

喖???????я??????????

??喙???Ψ?????????????????≥/??喕-J
FU
BM

+
%BJSZ
4DJ

喖???????喙§Ψ????¨Ψ???Δ???

??????5-3?????????喕-J
FU
BM

+
%BJSZ
4DJ

喖?

Ψ????臺????????且ブ??????????????喙

??????:,4&???嘔??????????????喙Ψ???

?臺?????+\",45\"5&SL\",5?????Ⅹ?????且ブ???

????????

????Ψ????臺????????????喕-J
FU

BM

\"$4
PNFHB

喨:BP
FU
BM

1FFS
+

喖?

乳鐵蛋白及亞麻酸乳鐵蛋白和亞麻酸對KYSE450荷瘤裸鼠的影響

7

科學研究

（3）短鏈脂肪酸在未成熟腸道中的抗炎研究

????????喕/&$喖??〤??????????喙????

?????????俁????嘔?俁??喙4$'\"??????????

?(13\"?????????И??喕4$'\"喖???????σ???

Ψ??????????/&$七??????????喕;IFOH
FU
BM

1M04

0/&

喖?

?λ?????????喙??4$'\"?????????????

????????喙??????????????????喕???

DMBVEJOT?PDDMVEJO喖??????Ⅹ?????-*?????????

???咹???嘔??/&$????喙????喙??И???????

???1*,\",5????32??????????/&$喕(BP
FU
BM

\"N
+

1IZTJPM
(BTUSPJOUFTU
-JWFS
1IZTJPM

喨:BOH
FU
BM

VOQVCMJTIFE喖?

丁酸在體內(nèi)外炎癥反應(yīng)條件下刺激未成熟腸道屏障增強

8

（4）微生物耐藥性風險評估

????????????????????喙???????????

??⒑??????К???????ま???喙???????????

???????????且?????????喙????я??Ψ??

七????????????????↖???喙???∝???↖???

??????喙?????↖???喕8V
FU
BM

#JPMPHZ

喖?

????∝???????????Ψ??????????喙???

???喙??????????λ?Ψ???????§??????喙

?ц??喙???????倍λCMB5&.?DGY\"???????℉???

?喙?????????喙????ц??喙?????К??????

?喕%POH
FU
BM

+
%BJSZ
4DJ


\"OUJCJPUJDT

喖?

科學研究

再生糞便處理步驟和不同的墊料樣品中主要菌科的差異性

9

重大項目


??????????????????????????????

??喙?????

?????????????????倍?э????????喙???

??

??????喕????喖?????????э?????И????

?????喙?????


?????????日??湊Ψ????????/??喙????

???

????? ??

????湊Ψ?????Ь???????????

??喙?????

?????????喙????????七?????????Ь???

??喙???????

科學研究

公益性行業(yè)(農(nóng)業(yè))科研專項啟動會

10

科學研究

科研平臺


Ψ?????俁?


???????俁?


???????俁?

?俁??????



??????俁?


?????俁?


??????俁?


?????俁?


???俁??

1 2

3 4

5 6

7 8 9

11

科技獎勵


??????ρま? ?????ρま?

????????????????????喕2021?喖


??????ρま? ?????ρま?

?э?Ψ?????????????產(chǎn)?????????喕2012?喖


??????ρま? ?????ρま?

??????????????????喕1999?喖

?ま????????? ?ま??????????


????????????????????喕2019?喖

??????э????? ??????э??????


???????七????????喕2019?喖


?????二??????ま? ????二??????ま?

??湊Ψ????????????????????喕2019?喖


??????二????ρま? ?????二????ρま?

??湊Ψ??????????????喕2019?喖


???????ρま? ??????ρま?

?????????????????喕2019?喖


????????ま? ???????ま?

???????倍???產(chǎn)?????????喕2017?喖


???????ρま? ???????ρま?

????э??????????????喕2011?喖

成果榮譽

12

成果榮譽

13

成果榮譽

標準制定


???????ち
8
????????せ??????????????

??喕GB/T 20014.8-2013喖


?????????????????????喕 NY/T 4050-2021喖


???Ψ????????????????????????

喕 NY/T 4051-2021 喖


???Ψ???????????????????????

喕 NY/T 4052-2021 喖


???Ψ??????????????????喕 NY/T 4053-2021 喖


???Ψ??????????????????????????

喕 NY/T 4054-2021 喖


??Ψ???????????????
??????????????

???喕NY/T3799-2020喖


???????????????????????????????

喕NY/T 3462-2019喖


??Ψ??Ⅵ?????
???????????????????

喕NY/T 3513-2019喖


??Ψ?嘆???? M1 ????????????????????

喕NY/T 3314-2018喖


??Ψ???????????????????????

喕NY/T 3313-2018喖


??Ψ? L-?????????????????????

喕NY/T 3130-2017喖

14

成果榮譽


???????
???????????喕喖?
喙???二??

?8???


??????

?????Ψ?
喙???二??????8


????????
????????????????????ー?

喙???二??????8


???
????????????????喕?喖?
喙????

?8?????


???
???????????喕喖?
喙???二?????8

?


??????

????????????????????
喙??

?8???????


???
??
???倍???????日??????
喙???二?

?8????


???????
??
??????????????????
喙?

?8??


???
??????????????????
喙??????8



??????????
??????????????????????

??
喙???二??????8

編著

15

榮譽


?喙?????????а?\"HSJDVMUVSF???


?喙????????а?5PYJOT???


?喙?????????????二???????????


?喙??????????э???????


?喙?????????二???????????


?喙????????????я?
?э?????????


?喙???????????????二??????


?喙??????二????七????????????ま??


?喙??????а?\"OJNBM???


?喙?????????а?+PVSOBM
PG
%BJSZ
4DJFODF???


?喙????????二???????????????


?喙??????????????????七?????э?

???

成果榮譽

16

成果榮譽

代表性論文

一、奶牛健康養(yǎng)殖與牛奶品質(zhì)形成機理領(lǐng)域

1. Liu S, Moon CD, Zheng N, Huws S, Zhao S, Wang J. Opportunities and challenges

of using metagenomic data to bring uncultured microbes into cultivation.

Microbiome. 2022,12;10(1):76.

2. He Y, Zhang X, Li M, Zheng N, Zhao S, Wang J. Coptisine: A natural plant

inhibitor of ruminal bacterial urease screened by molecular docking. Science of

the Total Environment. 2022,808:151946.

3. Yang YG, Zheng N, Zhao XW, Yang JH, Zhang YD, Han RW, Zhao SG, Li SL,

Wen F, Wang JQ. Changes in whey proteome with lactation stage and parity in

dairy cows using a label-free proteomics approach. Food Research International.

2020,128:108760.

4. Zhang XY, Zhao SG, He Y, Zheng N, Yan XH, Wang JQ. Substitution of residues

in UreG to investigate UreE interactions and nickel binding in a predominant

urease gene cluster from the ruminal metagenome. International Journal of

Biological Macromolecules. 2020,161,1591-1601.

5. Luo CC, Zheng N, Zhao SG, Wang JQ. Sestrin2 Negatively Regulates Casein

Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion

or Supplementation in Cow Mammary Epithelial Cells. Journal of Agricultural

and Food Chemistry. 2019,67(17):4849-4859.

6. Zhao SG, Li GD, Zheng N, Wang JQ, Yu ZT. Steam explosion enhances

digestibility and fermentation of corn stover by facilitating ruminal microbial

colonization. Bioresource Technology. 2018,253:244-251.

17

7. Zhang YD, Li P, Zheng N, Jia ZW, Meruva N, Ladak A, Cleland G, Wen F, Li SL,

Zhao SG, Wang JQ. A metabolomics approach to characterize raw, pasteurized,

and ultra-high temperature milk using ultra-performance liquid chromatographyquadrupole time-of-flight mass spectrometry and multivariate data analysis.

Journal of Dairy Science. 2018,101(11):9630-9636.

8. Luo CC, Zhao SG, Dai WT, Zheng N, Wang JQ. Proteomic Analysis of Lysosomal

Membrane Proteins in Bovine Mammary Epithelial Cells Illuminates Potential

Novel Lysosome Functions in Lacatation. Journal of Agricultural and Food

Chemistry. 2018,66(49):13041-13049.

9. Yang YX, Zheng N, Zhao XW, Yang JH, Zhang YD, Han RW, Qi YX, Zhao SG,

Li SL, Wen F, Guo TJ, Zang CJ, Wang JQ. Changes in bovine milk fat globule

membrane proteins caused by heat procedures using a label-free proteomic

approach. Food Research International. 2018, 113:1-8.

10. Jin D, Zhao SG, Zheng N, Bu DP, Yves B, Stuart E. Denman, Christopher S.

McSweeney, Wang JQ. Differences in Ureolytic Bacterial Composition between

WKH5XPHQ'LJHVWDDQG5XPHQ:DOO%DVHGRQXUH&*HQH&ODVVL?FDWLRQFrontiers

in Microbiology. 2017,8:385.

11. Yang YX, Zheng N, Zhao XW, Zhang YD, Han RW, Zhao SG, Yang JH, Li SG,

Guo TG, Zang CJ, Wang JQ. N-glycosylation proteomic charac-terization and

cross-species comparison of milk whey proteins from dairy animals. Proteomics.

2017,17(9):1-8.

成果榮譽

18

1. Gao YN, Wang ZW, Yang X, Wang JQ, Zheng N. Aflatoxin M1 and ochratoxin

A induce a competitive endogenous RNA regulatory network of intestinal

immunosuppression by whole-transcriptome analysis. Science of the Total

Environment. 2022 ,14:158777.

2. Du B, Meng L, Liu H, Zheng N, Zhang Y, Zhao S, Li M, Wang J. Diversity and

proteolytic activity of Pseudomonas species isolated from raw cow milk samples

across China. Science of the Total Environment. 2022,10;838(Pt 3):156382.

3. Yao Q, Gao Y, Fan L, Wang J, Zheng N. 2'-Fucosyllactose Remits ColitisInduced Liver Oxygen Stress through the Gut-Liver-Metabolites Axis. Nutrients.

2022,8;14(19):4186.

4. Wang ZW, Gao YN, Huang X, Huang SN, Yang X, Wang JQ, Zheng N.

Metabolomics analysis underlay mechanisms in the renal impairment of

mice caused by combination of aflatoxin M1 and ochratoxin A. Toxicology.

2021,11(458)152835.

5. Meng L, Liu HM, Lan T, Dong L, Hu HY, Zhao SG, Zhang YD, Zheng N, Wang

JQ. Antibiotic resistance patterns of pseudomonas spp. isolated from raw milk

revealed by whole genome sequencing. Frontiers in Microbiology. 2020,11,1005.

6. Li HY, Yang HG, Li P, Li M, Yao QQ, Zhang YD, Wang JQ, Zheng N. Maillard

reaction products with furan ring, like furosine, cause kidney injury through

triggering ferroptosis pathway. Food Chemistry. 2020,319:126368.

二、奶產(chǎn)品質(zhì)量安全風險評估和營養(yǎng)功能評價領(lǐng)域

成果榮譽

19

7. Zhou XW, Qu XY, Zheng N, Su CY, Wang JQ, Helene S. Large scale study of the

within and between spatial variability of lead, arsenic, and cadmium contamination

of cow milk in China. Science of the Total Environment. 2019,650,3054-3061.

8. Gao YN, Li SL, Bao XY, Luo CC, Yang HG, Wang JiQ, Zhao SG, Zheng

N. Transcriptional and Proteomic Analysis Revealed a Synergistic Effect of

$àDWR[LQ0DQG2FKUDWR[LQ$0\\FRWR[LQVRQWKH,QWHVWLQDO(SLWKHOLDO,QWHJULW\\

of Differentiated Human Caco-2 Cells. Journal of Proteome Research.

2018,17(9):3128-3142.

9. Meng L, Liu HY, Dong L, Zheng N, Xing MR, Zhang YD, Zhao SG, Wang JQ.

,GHQWL?FDWLRQDQGSURWHRO\\WLFDFWLYLW\\TXDQWL?FDWLRQRI3VHXGRPRQDVVSSLVRODWHG

from different raw milks at storage temperatures. Journal of Dairy Science.

2018,101:2897-2905.

10. /L+</L0/XR&&:DQJ-4=KHQJ1/DFWRIHUULQH[HUWVDQWLWXPRUH?HFWV

by inhibiting angiogenesis in a ht29 human colon tumor model. Journal of

Agricultural and Food Chemistry. 2017,65(48):10464-10472.

11. Chen L, Wen F, Li M, Guo XD, Li SL, Zheng N, Wang JQ. A simple aptamerEDVHGàXRUHVFHQWDVVD\\IRUWKHGHWHFWLRQRIDàDWR[LQELQLQIDQWULFHFHUHDOFood

Chemistry. 2017,215:377-382.

成果榮譽

20

???喙???　??????????喙介?????????

倍ま?????ж??Ψ?ж???????喙?????二?????

?????

??э?Ψ??????????????????喙??э?Ψ???э

???Ψ???????э?Ψ???????э?Ψ???Ь????

?喙????　??????????????????э?э???

??Ь?????э?Ψ?????日?

?????喙э?Ψ?????????????????Ψ?

ж???喙??????в??Ψ?ж???э?Ψ????俁?喙

?Ψ?ж?????э?Ψ?????

服務(wù)行業(yè)

21

服務(wù)行業(yè)

22

???????????????????????????ま???

?э???喙?　λ????????????????????????

?????????????????????????喙??λ????

???喙????????喙?　λ????????????日?

?????7?????????я????ち??К?喙????

??????喙?????????????????????????

??叛??喙????ま????????????????я??

??喙??я?????喙???????????????????

????????????????????????????

國際交流

23

?????喙???　??????????喙????喙??

????喙??????喙??????ま??????喙????

??喙?????????喙??????????/???????

???

團隊風采

24